SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.
Identifieur interne : 000260 ( Main/Exploration ); précédent : 000259; suivant : 000261SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.
Auteurs : Rafal Butowt [Pologne] ; Katarzyna Bilinska [Pologne]Source :
- ACS chemical neuroscience [ 1948-7193 ] ; 2020.
Abstract
The novel SARS-CoV-2 virus has very high infectivity, which allows it to spread rapidly around the world. Attempts at slowing the pandemic at this stage depend on the number and quality of diagnostic tests performed. We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at the earliest stages, prior to onset of symptoms or even in asymptomatic people, as compared to commonly used sputum or nasopharyngeal swabs. Here we emphasize that the nasal cavity olfactory epithelium is the likely site of enhanced binding of SARS-CoV-2. Multiple non-neuronal cell types present in the olfactory epithelium express two host receptors, ACE2 and TMPRSS2 proteases, that facilitate SARS-CoV-2 binding, replication, and accumulation. This may be the underlying mechanism for the recently reported cases of smell dysfunction in patients with COVID-19. Moreover, the possibility of subsequent brain infection should be considered which begins in olfactory neurons. In addition, we discuss the possibility that olfactory receptor neurons may initiate rapid immune responses at early stages of the disease. We emphasize the need to undertake research focused on additional aspects of SARS-CoV-2 actions in the nervous system, especially in the olfactory pathway.
DOI: 10.1021/acschemneuro.0c00172
PubMed: 32283006
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000197
- to stream PubMed, to step Curation: 000197
- to stream PubMed, to step Checkpoint: 000217
- to stream Ncbi, to step Merge: 003924
- to stream Ncbi, to step Curation: 003924
- to stream Ncbi, to step Checkpoint: 003924
- to stream Main, to step Merge: 000260
- to stream Main, to step Curation: 000260
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.</title><author><name sortKey="Butowt, Rafal" sort="Butowt, Rafal" uniqKey="Butowt R" first="Rafal" last="Butowt">Rafal Butowt</name><affiliation wicri:level="1"><nlm:affiliation>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz</wicri:regionArea><wicri:noRegion>85-94 Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="Bilinska, Katarzyna" sort="Bilinska, Katarzyna" uniqKey="Bilinska K" first="Katarzyna" last="Bilinska">Katarzyna Bilinska</name><affiliation wicri:level="1"><nlm:affiliation>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz</wicri:regionArea><wicri:noRegion>85-94 Bydgoszcz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32283006</idno><idno type="pmid">32283006</idno><idno type="doi">10.1021/acschemneuro.0c00172</idno><idno type="wicri:Area/PubMed/Corpus">000197</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000197</idno><idno type="wicri:Area/PubMed/Curation">000197</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000197</idno><idno type="wicri:Area/PubMed/Checkpoint">000217</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000217</idno><idno type="wicri:Area/Ncbi/Merge">003924</idno><idno type="wicri:Area/Ncbi/Curation">003924</idno><idno type="wicri:Area/Ncbi/Checkpoint">003924</idno><idno type="wicri:Area/Main/Merge">000260</idno><idno type="wicri:Area/Main/Curation">000260</idno><idno type="wicri:Area/Main/Exploration">000260</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.</title><author><name sortKey="Butowt, Rafal" sort="Butowt, Rafal" uniqKey="Butowt R" first="Rafal" last="Butowt">Rafal Butowt</name><affiliation wicri:level="1"><nlm:affiliation>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz</wicri:regionArea><wicri:noRegion>85-94 Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="Bilinska, Katarzyna" sort="Bilinska, Katarzyna" uniqKey="Bilinska K" first="Katarzyna" last="Bilinska">Katarzyna Bilinska</name><affiliation wicri:level="1"><nlm:affiliation>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz</wicri:regionArea><wicri:noRegion>85-94 Bydgoszcz</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS chemical neuroscience</title><idno type="eISSN">1948-7193</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel SARS-CoV-2 virus has very high infectivity, which allows it to spread rapidly around the world. Attempts at slowing the pandemic at this stage depend on the number and quality of diagnostic tests performed. We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at the earliest stages, prior to onset of symptoms or even in asymptomatic people, as compared to commonly used sputum or nasopharyngeal swabs. Here we emphasize that the nasal cavity olfactory epithelium is the likely site of enhanced binding of SARS-CoV-2. Multiple non-neuronal cell types present in the olfactory epithelium express two host receptors, ACE2 and TMPRSS2 proteases, that facilitate SARS-CoV-2 binding, replication, and accumulation. This may be the underlying mechanism for the recently reported cases of smell dysfunction in patients with COVID-19. Moreover, the possibility of subsequent brain infection should be considered which begins in olfactory neurons. In addition, we discuss the possibility that olfactory receptor neurons may initiate rapid immune responses at early stages of the disease. We emphasize the need to undertake research focused on additional aspects of SARS-CoV-2 actions in the nervous system, especially in the olfactory pathway.</div></front></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Butowt, Rafal" sort="Butowt, Rafal" uniqKey="Butowt R" first="Rafal" last="Butowt">Rafal Butowt</name></noRegion><name sortKey="Bilinska, Katarzyna" sort="Bilinska, Katarzyna" uniqKey="Bilinska K" first="Katarzyna" last="Bilinska">Katarzyna Bilinska</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000260 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000260 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32283006
|texte= SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32283006" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |